Ukrainian Antarctic Journal

No 12 (2013): Ukrainian Antarctic Journal
Articles

Long stay effects in the Antarctic on ultrastructure and platelet function in people with load hypoxic

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  • E. V. Rozova,
  • Y. V. Moiseyenko
E. V. Rozova
A. A. Bogomoletz Institute of Physiology of NAS of Ukraine, Kyiv
Y. V. Moiseyenko
A. A. Bogomoletz Institute of Physiology of NAS of Ukraine, Kyiv
DOI: https://doi.org/10.33275/1727-7485.12.2013.273
Published December 15, 2013
Keywords
  • platelets,
  • mitochondria,
  • hypoxia,
  • winterers,
  • Antarctica
How to Cite
Rozova, E. V., & Moiseyenko, Y. V. (2013). Long stay effects in the Antarctic on ultrastructure and platelet function in people with load hypoxic. Ukrainian Antarctic Journal, (12), 307-314. https://doi.org/10.33275/1727-7485.12.2013.273

Abstract

The work is devoted to the study of changes in the platelets ultrastructure (in winterers) in hypoxic stimulation before and after a long stay in Antarctica. It is shown that the ultrastructural parameters of platelets in Antarctic winterers significantly modified. Changes in tension indicates a platelet function and probably progenitor cells. Reaction of winterer’ platelets to hypoxic stimulation have the characteristic features. They can be considered as a compensatory-adaptive. The mechanisms of such transformations are characterized by the increase of the functional activity of organelles due to a moderate degree of edema, which may indicate an increase in energy production and activation of glycolysis.

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References

  1. Amosova, E.N. (2009). Novy`e standarty` tromboliticheskoj, antikoagulyantnoj i antitrombocitarnoj terapii infarkta miokarda s pod``emom segmenta ST po obe storony` Atlantiki.E.N. Amosova [New standards of the thrombolytic, anticoagulant and antithrombotic therapy of the heart attack with the ST segment elevation both sides of the Atlantic]. Serce і sudini, 2, 4-11.
  2. Vashkinel`, V.K., & Petrov, M.N. (1982). Ul`trastruktura i funkciya trombocitov cheloveka [Ultrastructure and function of human platelets]. Leningrad, Nauka.
  3. Zabrodina, L.P., Suxorukov, V.I., Moiseenko, E.V. et al. (2009). Vliyanie predvaritel`noj trenirovki nizkochastotnoj stimulyaciej na adaptivny`e perestrojki cerebral`nogo e`lektrogeneza i pokazateli samoocenki cheloveka v usloviyax Antarktiki [The effect of low-frequency pre-stimulation on the adaptive reconstructions of the cerebral electrogenesis and the parameters of human self evaluation in the Antarctic conditions]. Teor. і eksperim. med., 3, 36-42.
  4. Danilov, I.P. (2008). Trombocity`: novy`j vzglyad na ix rol` v organizme [Platelets: a new look on their role in the body]. Med. novosti, 9, 17-19.
  5. Karupu, V.Ya. (1984). E`lektronnaya mikroskopiya [Electron microscopy]. Kyiv, Vishha shkola.
  6. Kolosova, E.N., Vasilenko, I.A., & Kovaleva, L.G. (2011). Ocenka morfofunkcional`nogo sostoyaniya trombocitov u bol`ny`x idiopaticheskoj trombocitopenicheskoj purpuroj metodom vital`noj komp`yuternoj morfometrii [An evaluation of the morphofunctional state of the platelets in patients with idiopathic thrombocytopenic purpura by vital computer morphometry]. Byull. SO RAMN, 31(2), 58-63.
  7. Terez, E`.I., Vashhenko, V.N., Dolgij, S.O. et al. (2007/2008). Monitoring parametrov atmosfery` v Ukraine i na antarkticheskoj stancii «Akademik Vernadskij»: aktual`nost` issledovanij, apparaturnoe obespechenie, koncepciya razvitiya [Monitoring the atmosphere’s parameters in Ukraine and at the Antarctic Station Akademik Vernadsky: urgency of research, necessary equipment, development concept]. Ukrainian Antarctic Journal, 6-7, 143-149.
  8. Zlobina, G.P., Brusov, O.S., Morozova, M.A., & Beniashvili, A.G. (2009). Osobennosti vy`deleniya i sostoyanie trombocitov u bol`ny`x shizofreniej [Specifics of isolation and state of the platelets in schizophrenia patients]. Zhurn. nevrologii i psixiatrii, 10, 47-50.
  9. Reznikov, K.M. (1998). Obshhie mexanizmy` formirovaniya otvetny`x reakcij organizma na vozdejstvie faktorov okruzhayushhej sredy` [General mechanisms of the formation of a body’s responses to the effects of the environmental factors]. Prikladny`e informacionny`e aspekty` mediciny`. Sb. nauchn. rabot, 1, 4-9.
  10. Rozova, K.V. (2013). Strukturny`e i funkcional`ny`e izmeneniya biologicheskix bar`erov i mitoxondrial`nogo apparata legkix i serdcza i ix rol` v obespechenii organizma kislorodom pri gipoksii i stresse: dis. ... dokt. biol. nauk :03.00.13 [Structural and functional changes in the biological barriers and mitochondrial apparatus of the lungs and the heart and their role in providing the body with oxygen under hypoxia and stress: A doctoral thesis]. Kyiv.
  11. Skulachev, V.P. (2001). Kislorod i yavleniya zaprogrammirovannoj smerti [Oxygen and the phenomena of the programmed death]. Rossijskij biomedicinskij zhurnal, 5, 116-126.
  12. Sudakova, Yu.V., Bakeeva, L.E., & Cyplenkova, V.G. (1999). Destruktivny`e izmeneniya mitoxondrij kardiomiocitov cheloveka pri alkogol`nom porazhenii serdcza [Destructive changes in the human mitochondrial cardiomiocytes under the alcohol-induced heart damage]. Arxiv patologii, 9, 19-23.
  13. Tashke, K. (1980). Vvedenie v kolichestvennuyu cito-gistologicheskuyu morfologiyu [Introduction into quantitative cyto-histological morphology]. Buxarest: Izd-vo Akademii SRR.
  14. Kovalenko, V.N., Gavrish, A.S., Gulaya, N.M. et al. (2001). Ul`trastruktura trombocitov i disfunkciya NO-sistemy` u bol`ny`x s revmatoidny`m artritom [Platelet ultrastructure and the NO-system disdunction in rheumatoid arthritis patients]. Ukr. med. chasopis, 3, 129-132.
  15. Filippova, O.I., Koloskov, A.V., & Stolicza, A.A. (2012). Metody` issledovaniya funkcional`noj aktivnosti trombocitov (obzor literatury`) [Methods of the research of the functional activity of platelets (a review)]. Transfuzologiya, 13(2), 493-514.
  16. Xem, A., & Norman, D. (1983). Gistologiya [Histology]. Moscow, Mir. V. 2.
  17. Vashkinel`, V.K., Petrov, M.N., Almazov, V.A., & Safronnikov, L.V. (1981). E`lektronno-gistoximicheskoe i morfofunkcional`noe issledovanie trombocitov cheloveka posle priema acetilsalicilovoj kisloty` [Electron-hystochemical and morphofunctional research of human platelets after taking acetylsalicilic acid]. Probl. gematol. i perelivaniya krovi, 9, 40-44.
  18. Portnichenko, V.I., Nosar, V.I., Portnichenko, A.G. et al. (2006). Changes in breathing and mitochondrial respiration in rats living in altitude during intermittent hypoxia training: VIII World Congress of the International Society for Adaptive Medicine (ISAM) (21-24 June 2006, Russia, Moscow). –2006. –p. 162.
  19. Clauser, S., & Cramer-Borde, E. (2009). Role of platelet electron microscopy in the diagnosis of platelet disorders. Semin. Thromb. Hemost., 35(2), 213-223.
  20. Collet, J.P., & Montalescot, G. (2009). Platelet function testing and implication for clinical practice. Cardiovasc. Pharmacol. Ther., 14(3), 157-169.
  21. Fujimi, S., MacConmara, M.P., Maung, A.A. et al. (2006). Platelet depletion in mice increases mortality after thermal injury. Blood, 107(ll), 4399-4406.
  22. Joseph, R., Riddle, J.M., Welch, K.M., & D'Andrea, G. (1989). Platelet ultrastructure and secretion in acute ischemic stroke. Stroke, 20, 1316-1319.
  23. Watso, S.P., & Authi, K.S. (1996). Platelets. Oxford.