Ukrainian Antarctic Journal

No 8 (2009): Ukrainian Antarctic Journal
Articles

Dysadaptation mechanisms of the human's in Antarctic

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  • E. V. Moiseyenko
E. V. Moiseyenko
A.A. Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine, Kyiv, National Antarctic Scientific Center, Ministry of Education and Science of Ukraine, Kyiv
DOI: https://doi.org/10.33275/1727-7485.8.2009.478
Published December 16, 2009
Keywords
  • dysadaptation,
  • adaptation,
  • Antarctic conditions,
  • hypoxic status,
  • gene polymorphism,
  • extreme conditions,
  • biological rhythms
    • ...More
    Less
How to Cite
Moiseyenko, E. V. (2009). Dysadaptation mechanisms of the human’s in Antarctic. Ukrainian Antarctic Journal, (8), 475-488. https://doi.org/10.33275/1727-7485.8.2009.478

Abstract

Long-term complex monitoring medical-biological researches of the human's functional systems status at the prolonged stay in the conditions of isolation at the off-shore (coast) Antarctic station were focused on finding out of mechanisms of dysadaptative disorders development of integrative and oxygen-transport systems of organism in the absence of essential reduction of the oxygen content in atmospheric air. Work was based on the results of medical-biological studies, which were conducted with participation of the crew members of the Antarctic station Academician Vernadskiy (Vernadsky – 65° 14'43"S; 64° 15'24"W). The average age of examinees was 39,8±2,4 years (130 men). The medical-biological studies included the modern clinic-laboratory, functional, instrumental, biochemical, immunologic, genetic, statistical methods. The participants' examinations of the expedition were conducted before expedition, at a period of transatlantic transition, on Antarctic station (in mode of the monitoring by means of telemedical connection), after returning from expedition. In Antarctic the unique complex of physical, chemical, biological, of social, nature (the metheoheliogeophysical, biorhythmological, deprivation) factors, exceeding by power and duration, affect a human. Long influence of these factors brings to the adaptation processes disorders and dysadaptative development. It is shown that the mechanisms of dysadaptative disorders of oxygen-transport systems of the human organism at the long stay under the influence of the complex of extreme factors of Antarctic expedition developed on the background of the chain neurohumoural, neuroimmune, metabolic, celluar dysfunctions, which indicated on the presence of signs of long stressful condition (the stress-syndrome) that brings to adaptative mechanisms exhaustion of compensation and requires using the methods of correction. At the long stay of a human on the coast Antarctic station, there was revealed the seasonal dynamics of adaptative-dysadaptative rebuildings of regulative and oxygen-transport systems, there was revealed the presence of signs of stressful status and development of tissue hypoxia. It was shown the pathogenic mechanisms of development of dysadaptative disorders of integrative systems (change in cerebral electrogenesis, the activation of sympathoadrenal system, immune malresistance),
respiratory, circulatory and hemic mechanisms of regulation of organism oxygen modes (the fall in efficiency and economy of the regulation mechanisms). It is shown the role of biorhythmologic and heliophysical factors of environment in development of dysadaptative disorders. It is for the first time fullfilled the genetic typization of the participants of Antarctic expedition on the presence of an allele polymorphism of specific genetic factor (hypoxia inducted factor - HIF-1α). The significance of such human gene HIF-1α polymorphism is studied in correction to development of adaptative-dysadaptative rebuildings of the functional systems at a continuous stay in Antarctic. It is shown the stabile reduction of regulation mechanisms of an organism oxygen modes under influence of Antarctic factors and hypoxia loading among winterers with C/T polymorphism of the gene HIF-1α, that has prognostic importance and opens way to deepened study of the molecular mechanisms role in development adaptative-dysadaptative processes in a human in extreme conditions.

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References

  1. Aidaraliev, A.A., Maksimov, A.L., & Chernook, T.B. (1987). Adaptation capabilities of polar explorers in Antarctic mountains. Kosmicheskaia biologiia i aviakosmicheskaia meditsina, 21(6), 62–66.
  2. Chernous, S., Ilyin, V., Milinevsky, G., & Moiseenko, Y. (2002). Heart rate variability parameters in variations at geomagnetic disturbances in Arctic and Antarctic regions Physics of Auroral Phenomena. Proceedings of the XXVAnnual Seminar. Apatity, 2002. pp. 157–160
  3. Kurafid. (1988). British Antarctic Survey. Medical Handbook. p. 281
  4. Moiseenko, E.V. (2002). Medical and Biological Researches of Ukraine in Antarctic. In “Astroeco-2002: Current Status and Prospects of International Research in Observational Astronomy and Extreme Physiology in the Elbrus Region”. Abstracts. Terskol, Russia, August 12–16, 2002. Kyiv-Terskol, Hypoxia, Ecology, 2002. p. 151.
  5. Moiseenko, E.V., Stezhka, V.A., Lastovchenko, V.V., Kovalenko, T.M., Perevoznikov, O.M., Bilko, T.A., Dmitrucha, N.M., Wojnar, J., & Bakunovsky, A.M. (2003). Human psychophysiology in extremal environment. Annales Universitatae Mariae Curie-Sklodowska, Lublin-Polonia. Section “Medicina”, 58, S.13, iss. 162, 316–321
  6. Moiseyenko, Ye. (2004). Medical-biology aspects of the Antarctic expedition at the Academic Vernadsky station. Abstracts Second Ukrainian Antarctic Meeting 2 UAM. Kyiv, Ukraine, June 22–24, 2004. Kyiv, 2004. p. 168
  7. Moiseyenko, Ye., Madiar, S. (2004).Polychromatic spectrum modification on the psychic-physical human status in Antarctica. Abstracts volume XXVIII SCAR Open Science Conference Antarctica and the Southern Ocean in the Global System. Bremen, Germany, June 25–31. 2004. – Bremen, 2004.– P. 1988.
  8. Moiseyenko, E.V. (2007). Human adaptation to Antarctic. Annales of hygiene and epidemiology,11(1), 84–87.
  9. Moiseyenko, E. V. (2008). Dysadaptation mechanisms and complex pathogenic correction of the human's functional systems disorders in Antarctic. The manuscript dissertation for the scientific degree of doctor of medical sciences, Kyiv, 2008. – P. 53
  10. Palinkas, L.A., Houseal, M., & Rosenthal, N.E. (1996). Subsyndromal seasonal affective disorder in Antarctica. Journal of Nervous and Mental Disease, 184, 530–534.
  11. Rushkovsky, S.R., Afanasieva, E.S., Bezrukov, V.E., & Moiseenko, E.V. (2006). The impact of the Antarctic stressful conditions on human genome instability. SCAR Open Science Conference. Hobart, Australia, July 12–14, 2006.
  12. Semenza, G. (2000). L.HIF-1: mediator of physiological and pathophysiological responses to hypoxia. Journal of Applied Physiology, 88, 1474–1480.