Ukrainian Antarctic Journal

No 8 (2009): Ukrainian Antarctic Journal
Articles

About involvement of peroxisome-proliferator-activated receptor gamma in mechanism of antiulcer action of melanin isolated from antarctic yeasts

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  • V. M. Kukharskyy,
  • N. V. Chyizhanska,
  • O. I. Tsyryuk
V. M. Kukharskyy
Kiev National Shevchenko University, Kyiv
N. V. Chyizhanska
Poltava State Agriculture Academy, Poltava
O. I. Tsyryuk
Kiev National Shevchenko University, Kyiv
DOI: https://doi.org/10.33275/1727-7485.8.2009.466
Published December 16, 2009
Keywords
  • melanin,
  • stress,
  • peroxisome proliferator-activated receptors gamma
How to Cite
Kukharskyy, V. M., Chyizhanska, N. V., & Tsyryuk, O. I. (2009). About involvement of peroxisome-proliferator-activated receptor gamma in mechanism of antiulcer action of melanin isolated from antarctic yeasts. Ukrainian Antarctic Journal, (8), 374-376. https://doi.org/10.33275/1727-7485.8.2009.466

Abstract

In acute experiments on 55 white rats we investigated one of the possible mechanisms of cytoprotective action of melanin via activation of peroxisome proliferator-activated receptors gamma. It was established that immobilization stress by Groisman and Karevina evoked in gastric mucosa the formation of ulcers, erosions and hemorrhages. Melanin in dose 5 mg/kg defended gastric mucosa against development of injuries evoked by stress. Irreversible selective antagonist of peroxisome proliferator-activated receptors gamma GW9662 in dose 1 mg/kg removed the cytoprotective action of melanin on formation of stress injuries. We concluded that antistress action on gastric mucosa in rats completely or partly is governed by activation of peroxisome proliferator-activated receptors gamma.

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References

  1. Chyizhanska, N., Tsyryuk, O., & Beregova, T. (2005). About the participation of nitric oxide in cytoprotection of melanin in the mucous membrane of the stomach. Bulletin of the problems of biology and medicine, 3, 56-59.
  2. Savitskiy, Ya., Kimakovich, V., & Beregova, T. (2002). New data on the action of melanin on gastric acid secretion and gastric mucosa. Programme and Abstracts 4th Parnas Conference "Molecular Mechanisms on Cell Activation: Biological Signals and Their Target Enzymes". Wroclaw, 2002, 108.
  3. Chyizhanska, N., Kukharskyy, V., Tzyryuk, O., & Beregova, T. (2005). The Influence of melanin on the expression of epithelial isoforms of nitric oxide synthase (eNOS) in the gastric mucosa of rats. Problems of ecological and medical genetics and clinical immunology, 5, 52-59.
  4. Inoue, H. (2005). Endogenous ligands for PPARs. Nippon Rinsho, 63(4), 578-583.
  5. Kim, C.S., Park, W.H., Park, J.Y. et al. (). Capsaicin, a spicy component of hot pepper, induces apoptosis by activation of the peroxisome proliferator-activated receptor gamma in HT-29 human colon cancer cells. J. Med. Food, 7(3), 267-273.
  6. Feige, J.N., Gelman, L., Michalik, L. et al. (2006). From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Progress in Lipid Research, 45(2), 120-159.
  7. Fajas, L., Auboeuf, D., Raspe, E. et al. (1997). The organization, promoter analysis, and expression of the human PPARgamma gene. The Journal of Biological Chemistry, 272(30), 18779-18789.
  8. Escher, P., & Wahli, W. (2000). Peroxisome proliferator-activated receptors: insight into multiple cellular functions. Mutatation Research, 448(2), 121-138.
  9. Michalik, L., & Wahli, W. (2006). Involvement of PPAR nuclear receptors in tissue injury and wound repair. Journal of Clinical Investigations, 116(3), 598-606.
  10. Hollands, C. (1986). The Animals (scientific procedures) Act 1986. Lancet, 2(8497), 32-33.