Ukrainian Antarctic Journal

No 8 (2009): Ukrainian Antarctic Journal
Articles

The influence of melanin on concentration of cortisol in the blood of the rats in conditions of stress action

PDF (Українська)
  • T.M. Falalyeyeva,
  • O. I. Tsyryuk,
  • N. V. Chyizhanska,
  • V. P. Zharova
T.M. Falalyeyeva
Department of Pharmaco-physiology of Institute of physiology of Biological faculty, Taras Shevchenko National University of Kyiv, Kyiv
O. I. Tsyryuk
Department of Pharmaco-physiology of Institute of physiology of Biological faculty, Taras Shevchenko National University of Kyiv, Kyiv
N. V. Chyizhanska
Poltava State Agriculture Academy, Poltava
V. P. Zharova
National Antarctic Scientific Center, Kyiv
DOI: https://doi.org/10.33275/1727-7485.8.2009.469
Published December 16, 2009
Keywords
  • melanin,
  • stress,
  • gastric mucosa,
  • injury,
  • cortisol
How to Cite
Falalyeyeva, T., Tsyryuk, O. I., Chyizhanska, N. V., & Zharova, V. P. (2009). The influence of melanin on concentration of cortisol in the blood of the rats in conditions of stress action. Ukrainian Antarctic Journal, (8), 386-390. https://doi.org/10.33275/1727-7485.8.2009.469

Abstract

Immobilizational stress exposure time of which was 24 hour evoked in gastric mucosa of rats formation of ulcers, erosions and hemorrhages with simultaneous drastic increase of cortisol blood level. Melanin defended gastric mucosa against development of injuries evoked by stress and at the same time reduced cortisol blood level by 1,81 times. It was concluded that a decrease in cortisol blood level against a background of melanin action is the result of active influence of melanin on one of the links of mechanism of cortisol liberation.

PDF (Українська)

References

  1. Biomedicinskaya e`tika [Bioethics]. (1997). Ed. by V.I. Pokrovskogo. Moscow. (In Russian).
  2. Golikov, P.P., Paxomova, G.V., Tveritneva, L.F., & Nikolaeva, N.I. (1995). Izmenenie v glyukokortikoid-svyazy`vayushhej funkcii transkortina pri ostry`x gastroduodenal`ny`x krovotecheniyax [Changes in glucocorticoid-binding function of transcortin under acute gastroduodenal bleedings]. Voprosy` medicinskoj ximii, 41, 48-50. (In Russian).
  3. Grojsman, S.D., & Karevina, T.G. (1979). O vliyanii atropina na stressorny`e porazheniya slizistoj obolochki zheludka u kry`s [On the action of atropin on stress leisions of the mucose layer of the stomach in rats]. Bibl. ukaz. VINITI. Dep. Rukopisi, 12, B/o 131. (In Russian).
  4. Lazebnik, L.V., Arbuzova, V.G., Sokolova, G.N. i dr. (2002). Rol` stressa v e`tiopatogeneze duodenal`noj yazvy` u molody`x pacientov [The role of stress in the ethiogenesis of the duodenal ulcer in young patients]. E`ksperimental`naya i klinicheskaya gastroe`nterologiya, 5, 30-37. (In Russian).
  5. Mal`cev, V.I., & Belousov, D.Yu. (2001). E`ticheskaya ocenka metodik provedeniya issledovanij [The ethical evaluation of research methods]. Ezhenedel`nik Apteka, 34(305). (In Russian).
  6. Nary`zhnaya, N.V., Maslov, L.N., & Lishmanov, Yu.B. (2000). Processy` biosinteza belka v serdechnoj my`shce i kardioprotektornoe dejstvie ligandov μ-opiatny`x receptorov pri immobilizacionnom stresse [Processes of protein synthesis in the heart muscle and cardioprotectory action of ligands of the μ-opiate receptors under immobilization stress]. Voprosy` medicinskoj ximii, 2. (In Russian).
  7. Podkolzin, A.A., Bol`shakov, G.V., Shany`gina, D.V., & Gurevich, K.G. (2001). Vy`delenie kortizola so slyunoj u bol`ny`x arterial`noj gipertenziej pri stomatologicheskom stresse: individual`ny`e osobennosti [Cortizol secretion with saliva in patients with arterial hypertension under stomatological stress: the individual peculiarities]. Rossijskij biomedicinskij zhurnal, 2, 209-211. (In Russian).
  8. Rekomendacii Komiteta po e`tike provodyashhim e`kspertizu biomedicinskix issledovanij [Recommendations of the Committee on ethics for the people conducting biomedical research]. Zheneva, 2000. (In Russian).
  9. Storozhkov, G.I., & Maly`sheva, E.A. (2001). Ocenka metodik provedeniya issledovanij [Evaluating research methods]. Kachestvennaya klinicheskaya praktika, 1, 21-30. (In Russian).
  10. Filaretovna, L.P., Bagaeva, T.R., Podvigina, T.T., & Morozova, O.I. (2002). Deficit produkcii glyukokortikoidov u kry`s, usilivaet ul`cerogenny`e e`ffekty` stimulov raznoj modal`nosti i intensivnosti [Deficit of glucocorticoid production in rats enhances ulcerogenetic effects of stimulae of various modality and intensity]. Rossijskij Fiziologicheskij zhurnal im. I.M. Sechenova, 88, 602-611. (In Russian).
  11. Frolkov, V.K., Polushina, N.D., Shvarcz, V.I. i dr. (1992). Gormonal`ny`e mexanizmy` patogeneza i terapii e`ksperimental`noj gastroduodenal`noj yazvy` pri pomoshhi metoda Okabe` [Hormonal mechanisms of pathogenesis and therapy of experimental gastroduodenal ulcer using the Okabe method]. Patologicheskaya fiziologiya i e`ksperimental`naya terapiya, 37-40. (In Russian).
  12. Christensen, N.J., & Jensen, E.W. (1994). Effect of psychosocial stress and age on plasma norepinephrine levels: a review. Psychosom. Med., 56., 77–83.
  13. Furr, M.O., Murray, M.J., & Ferguson, D.C. (1992). The effects of stress on gastric ulceration, T3, T4, reverse T3 and cortisol in neonatal foals. Equine Vet. J., 24, 37–40.
  14. Lau, J.Y., Lo, S.Y., Ng, E.K. et al. (1998). A randomized comparison of acute phase response and endotoxemia in patients with perforated peptic ulcers receiving laparoscopic or open patch repair. Am. J. Surg., 175(4), 325–327.
  15. Lechin, F., van derDijs, B., Rada, I. et al. (1990). Plasma neurotransmitters and cortisol in duodenal ulcer patients. Role of stress. Dig. Dis. Sci., 35(11), 1313-1319.
  16. Namiki, M. (1994). Aged people and stress. Nippon Ronen Igakkai Zasshi, 31, 85-95
  17. Orlicz-Szczesna, G., Jablonski, M., Gorzelak, M. (1994). Hypoplasia of G cells in long term steroid-treated rats after ultra-high dose of salmon calcitonin. Acta Histochem., 96, 379-386.
  18. Ruis, M.A., Te Brake, J.H., Engel, B. et al. (1997). The circadian rhythm of salivary cortisol in growing pigs: effects of age, gender, and stress. Physiol. Behav., 62, 623-630.